InVision Biomedical Chemical Analysis Techniques

InVision Biomedical employs sensitive analytical techniques for:

  • Characterization of the materials and their purity
  • Investigation of extractable substances, environmental contaminants, and manufacturing residuals.

The following include the techniques we routinely employ:

  1. UltraViolet/Visible (UV/VIS) Spectrophotometry – extractable substances
  2. High Performance Liquid Chromatography (HPLC) – purity of raw materials and analysis of extracts
  3. Gas Chromatography with Flame Ionization Detection (GC/FID) – purity of raw materials and analysis of extracts. GC techniques are particularly suited to the identification of volatile and semi-volatile species.
  4. Gas Chromatography with Mass Spectrometry Detection (GC/MS) – analysis of extracts, identification and quantification of contaminants or manufacturing residuals. The high sensitivity of mass spectrometry allows for detection of volatiles and semi-volatiles at sub-ppm levels.
  5. Liquid Chromatography with Mass Spectrometry Detection (LC/MS) – analysis of extracts, identification and quantification of contaminants or manufacturing residuals. We have found LC/MS to be well-suited to the detection and quantification of residual surfactants from device cleaning and other process steps.
  6. ESCA – this technique can detect subtle changes in the elemental composition of surfaces and is suitable for contaminant analysis as well as confirmation of surface stability through manufacturing process steps. We work closely with an allied laboratory for ESCA studies where an InVision investigator is present to guide the study.
  7. SEM/EDS – this combined technique can detect the elemental composition of surfaces or particulate material on a surface. EDS is suitable for evaluation of particulate contamination including aluminate polishing compound residuals. We work closely with an allied laboratory for SEM/EDS studies. Usually an InVision investigator is present to guide the study.
  8. ICP-MS – this technique is suitable for sub-ppm detection of heavy metal contamination of devices and materials. We work closely with an allied laboratory for ICP-MS studies.
  9. Fourier-Transform InfraRed (FTIR) spectroscopy - chemical identification and structural spectroscopy
  10. Nuclear Magnetic Resonance (NMR) spectroscopy - chemical identification and structural spectroscopy
  11. Two-dimensional NMR spectroscopy - Dr. Christ is a published expert

Call us today to request more information on FDA and CE Ophthalmic Device Regulatory Testing

Contact Information

InVision Biomedical
18226 McDurmott West,
Suite F
Irvine, CA 92614

Ph: (949) 872-2126
Fx: (949) 872-2754

Email Us

 

InVision is a BIOCOM Member

Copyright © InVision Biomedical All Rights Reserved. Developed by HQZ Experts.